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Reference Materials in Laboratory Testing

How characterized materials support calibration, method assessment, comparability, and measurement confidence.

Laboratory scene illustrating Reference Materials in Laboratory Testing

Educational scope: Laboratory documentation, analytical methods, and research recordkeeping only.

A measurement reference

Reference materials provide known or characterized properties that laboratories can use for calibration, method assessment, quality control, or assignment of values to other materials.

Certified and noncertified values

NIST distinguishes certified reference materials from other reference materials and research-grade test materials. Their documentation, traceability, uncertainty, and intended uses are not interchangeable.

Match the material to the purpose

The required characterization depends on how the material will be used. Laboratories should evaluate certificates, uncertainty statements, traceability, storage instructions, and expiration or validity information.

References and further reading

Research-use notice

This material is educational and does not provide medical, dosing, administration, or human-use guidance.

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