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FOR LABORATORY RESEARCH USE ONLY · NOT FOR HUMAN OR VETERINARY USE · 21+
Quality & Transparency · · 6 min read

Reference Materials in Laboratory Testing

How characterized materials support calibration, method assessment, comparability, and measurement confidence.

Laboratory scene illustrating Reference Materials in Laboratory Testing
Educational scope

Laboratory research education only. This article does not provide human or veterinary dosing, administration, diagnosis, treatment, or safety guidance.

BLUE COLLAR ORIGINALFrom question to documented conclusion
01ASKDefine one research question
02SOURCEFind and screen original literature
03CHECKCompare model, method, and endpoint
04RECORDDocument limits and open questions
Original educational graphic by Blue Collar Peptides · Share with attribution

A measurement reference

Reference materials provide known or characterized properties that laboratories can use for calibration, method assessment, quality control, or assignment of values to other materials.

Certified and noncertified values

NIST distinguishes certified reference materials from other reference materials and research-grade test materials. Their documentation, traceability, uncertainty, and intended uses are not interchangeable.

Match the material to the purpose

The required characterization depends on how the material will be used. Laboratories should evaluate certificates, uncertainty statements, traceability, storage instructions, and expiration or validity information.

References and further reading

Open the original sources and evaluate their methods, limitations, and applicability independently.

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Related education

Research-use notice

This material is educational and does not provide medical, dosing, administration, treatment, or human-use guidance. For laboratory research use only.

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